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The Leukemia/Bone Marrow Transplant Program of BC

Hematology Dictionary
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L

Large Granular Lymphocytic Leukemia
Large granular lymphocytic leukemia (LGL) is a chronic leukemia, which affects T-cells. LGL is a rare disease with important clinical differences from chronic lymphocytic leukemia.

Late Effects
Results of chemotherapy and/or radiotherapy, which only become apparent with long-term monitoring of the patient over a period of years. These are of particular concern in patients below the age of puberty.

Leukemia
From the Greek meaning, "white blood". Often referred to as cancer of the blood. Characterized by the widespread uncontrolled proliferation of large numbers of abnormal blood cells, usually of the white cell lineages, which take over the bone marrow and often spill out into the blood stream. Other organs that may also be affected include lymph nodes, spleen, and liver.

Leukemogenesis
The development of leukemia.

Leukepheresis
Method of separating blood into its liquid and cellular components and for the removal of white blood cells before returning the remainder of the blood to the patient. It is used to reduce the white cell count when chemotherapy is to be avoided, for example during pregnancy.

Leukocytes
Collective term for white blood cells.

Leucopoenia
Condition in which the number of white cells in the blood is greatly reduced. Leads to increased risk of infections.

Lineage
Describes cells with a common ancestry that is developing from the same type of identifiable immature cell.

Li-Fraumeni Syndrome
An inherited family trait carrying an increased risk of cancer during childhood and early adulthood.

Long-term Survival
Term used to describe the survival of leukemia patients who have been disease free for prolonged periods of time, usually at least five years. The chance of disease returning (relapse) decreases with time.

Lumbar Puncture
A procedure for removing spinal fluid from around the spinal cord using a fine needle in the lower part of the back. Samples are analyzed for evidence of any CNS leukemia. Also used to administer anti-cancer drugs to either prevent or cure CNS disease.

Lymph Nodes or Glands
Small structures found throughout the body, e.g. neck, groin, armpits, abdomen, which contain both mature and immature lymphocytes.

Lymphatic System
This consists of the spleen, lymph nodes and areas of lymphoid tissue such as the tonsils. It plays a major part of the body's IMMUNE RESPONSE.

Lymphocyte
A type of white blood cell, which is involved in the immune defenses of the body. There are two main types - B-cells and T-cells.

Lymphoid
Referring to the lymphatic system including lymphocytes and lymph nodes.

Lymphoma
A cancer, which originates in lymphoid tissue, including the lymph glands, liver, spleen, bowel and bone marrow. The disease results from the uncontrolled production of lymphocytes. The general term includes about a dozen different forms of the disease but there are two main categories: Hodgkin's disease and non-Hodgkin's lymphoma.

Lymphoproliferation
An increase in the production of lymphocytes. This may occur as a normal response to infection.

 

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The information in this glossary is cited with permission from the Leukemia Research Foundation web site.

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