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The Leukemia/Bone Marrow Transplant Program of BC

Hematology Dictionary
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D

Deletion
A chromosome abnormality in which part of a single chromosome has been lost.

Depletion
A laboratory procedure for reducing the numbers of specific cell types within bone marrow donated for transplantation, for example the removal of some types of lymphocytes. This may be to avoid "mismatch" problems (particularly in relation to unrelated donor transplants) or to remove a sub-set of potentially leukemic cells in an autograft.

Differentiation
The gradual maturation of a cell whereby its functions and properties become increasingly specialized. Leukemic cells are often poorly differentiated, i.e. they show immature characteristics.

Disseminated Disease
Disease in which the cancerous cells have spread from the tissue of origin to other organs.

Diuretic
A drug to stimulate the excretion of urine by the kidneys. May be used during chemotherapy to ensure the excretion of anti-cancer drugs.

DNA (Deoxyribonucleic acid)
Provides the essential building block for storing genetic material. There are 4 different chemical components of DNA (bases) arranged in coded sequence as genes, which determine an individual's inherited characteristics.

Donor Lymphocyte Infusion
If a patient who has had an allogeneic bone marrow transplant has a relapse, with return of the original disease, they may be given lymphocytes from the donor. This may eliminate the leukemia cells.

Down's Syndrome
A congenital condition in which some or all of the body cells have three copies of chromosome 21. This form of TRISOMY is associated with an increased risk of leukemia.

 

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The information in this glossary is cited with permission from the Leukemia Research Foundation web site.

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